null

PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12] (AGEL2256)

SKU:
AGEL2256
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
29F.1A12
Conjugation:
PerCP/Cyanine5.5
$203 - $491
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]

The PERCP-Cyanine5.5 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) is an essential tool for researchers studying immune checkpoint pathways and immune regulation in mice. This monoclonal antibody, clone 29F.1A12, is specifically designed to target CD279, also known as PD-1, a key immune checkpoint receptor that plays a crucial role in regulating T cell responses and maintaining immune tolerance.Within the field of immunology, PD-1 has emerged as a pivotal molecule in understanding how the immune system responds to various challenges, including infections, cancer, and autoimmune diseases. By targeting PD-1, researchers can modulate immune responses and potentially enhance anti-tumor immunity or regulate autoimmune reactions.

The PERCP-Cyanine5.5 Anti-Mouse CD279 (PD-1) Antibody (29F.1A12) offers high specificity and sensitivity in detecting PD-1 expression in mouse samples, making it a valuable tool for flow cytometry and immunofluorescence studies. Its precise targeting of the CD279 protein enables researchers to explore the role of PD-1 in immune responses, paving the way for innovative therapeutic strategies in cancer immunotherapy and autoimmune disease treatment.Overall, this antibody provides researchers with a reliable and effective means of investigating the functions of PD-1 in mouse models, contributing to the advancement of knowledge in immunology and the development of novel immunotherapies.

Product Title:PerCP/Cyanine5.5 Anti-Mouse CD279/PD-1 Antibody [29F.1A12]
SKU:AGEL2256
Size:50 Tests, 100 Tests, 200 Tests
Clone No:29F.1A12
Synonyms:PD-1; Programmed Death-1;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PerCP/Cyanine5.5 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q02242
Gene ID:18566
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts.

Related Products