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PerCP/Cyanine5.5 Anti-Human CD279/PD-1 Antibody [EH12.2H7] (AGEL3158)

SKU:
AGEL3158
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, κ
Clone:
EH12.2H7
Conjugation:
PerCP/Cyanine5.5
$287 - $995
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Description

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PerCP/Cyanine5.5 Anti-Human CD279/PD-1 Antibody [EH12.2H7]

The PD-1 Monoclonal Antibody (PERCP-Cyanine5.5 Anti-Human CD279, Clone EH12.2H7) offered by Assay Genie is a cutting-edge tool for researchers studying the PD-1 protein, a crucial regulator of immune responses. This monoclonal antibody, originating from mice, is specifically designed for high reactivity with human samples and is validated for use in flow cytometry applications.PD-1, or Programmed Cell Death Protein 1, is a key immune checkpoint receptor that plays a pivotal role in maintaining immune tolerance and preventing autoimmunity. Its interaction with ligands such as PD-L1 suppresses T cell activity, serving as a mechanism for immune evasion in diseases like cancer. The PD-1 antibody provides researchers with the ability to detect and quantify PD-1 expression in different cell populations, making it an invaluable tool for immunology and oncology studies.

Studies involving PD-1 have significant implications for the development of immunotherapies aimed at enhancing anti-tumor immune responses. By understanding the mechanisms of PD-1 signaling and its impact on immune function, researchers can advance the field of cancer immunotherapy and potentially improve treatment outcomes for patients with various malignancies. With its high specificity and sensitivity, the PD-1 Monoclonal Antibody from Assay Genie is an essential resource for investigating the role of PD-1 in immune regulation and disease pathogenesis.

Product Title:PerCP/Cyanine5.5 Anti-Human CD279/PD-1 Antibody [EH12.2H7]
SKU:AGEL3158
Size:20 Tests, 100 Tests, 200 Tests
Clone No:EH12.2H7
Synonyms:PDCD1;PD1;Protein PD-1;hPD-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PerCP/Cyanine5.5 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PerCP/Cyanine 5.5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q15116
Gene ID:5133
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

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