The PERCP Anti-Mouse LY-6G/LY-6C (GR-1) Antibody (Clone: RB6-8C5) is a vital tool for researchers studying immune cells in mice. This antibody is specifically designed to target the LY-6G/LY-6C (GR-1) protein present on the surface of neutrophils and inflammatory monocytes. The RB6-8C5 Antibody is highly specific and has been validated for use in flow cytometry, immunofluorescence, and other immunological techniques. Its strong binding affinity to LY-6G/LY-6C (GR-1) allows for accurate detection and analysis of these cell populations in various tissues and experimental models.
Neutrophils and inflammatory monocytes play crucial roles in the immune response to infections, inflammation, and cancer. By targeting the LY-6G/LY-6C (GR-1) protein, researchers can gain valuable insights into the dynamics of these immune cells and their involvement in disease pathology. This antibody is a valuable resource for studies focused on understanding the immune system and developing novel strategies for therapeutic interventions.
Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:
Swissprot:
P35461 P0CW03
Gene ID:
546644 ,17067
Storage Buffer:
Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
Gr-1 is a 21-25 kD protein also known as Ly-6G/Ly-6C. This myeloid differentiation antigen is a glycosylphosphatidylinositol (GPI)-linked protein expressed on granulocytes and macrophages. In bone marrow, the expression levels of Gr-1 directly correlate with granulocyte differentiation and maturation; Gr-1 is also transiently expressed on bone marrow cells in the monocyte lineage. Immature Myeloid Gr-1+ cells play a role in the development of antitumor immunity.