The PER2 Rabbit Monoclonal Antibody (CAB5107) is a high-quality antibody specifically designed for research involving the PER2 protein, a key regulator of circadian rhythms. This antibody, generated in rabbits, is highly specific and reactive with human samples, making it an ideal tool for studying the role of PER2 in circadian biology.PER2, a core component of the circadian clock, plays a critical role in regulating the timing of physiological processes and behaviors. Dysregulation of PER2 has been linked to various health conditions, including sleep disorders, metabolic diseases, and psychiatric disorders. By targeting PER2 with this antibody, researchers can investigate its functions and mechanisms in different cell types and tissues, advancing our understanding of circadian biology and its implications for human health.
Validated for use in Western blot applications, the PER2 Rabbit Monoclonal Antibody enables accurate detection and quantification of PER2 protein levels in experimental samples. Its high specificity and sensitivity make it a valuable tool for studies in chronobiology, neuroscience, and related fields, facilitating insights into the molecular mechanisms underlying circadian rhythms and their impact on physiology and pathology.
Product Name:
PER2 Rabbit Monoclonal Antibody
SKU:
CAB5107
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PER2 (O15055).
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
Purification Method:
Affinity purification
Gene ID:
8864
Clone Number:
ARC1134
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PER2 Rabbit mAb (CAB5107) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 3min.
