The PER2 Polyclonal Antibody (CAB3217) is a valuable tool for researchers studying the PER2 protein, which is a key component of the circadian clock that regulates daily rhythms in biological processes. This antibody, produced in rabbits, is highly specific for PER2 and has been validated for use in various experimental applications, including Western blotting.PER2 is involved in the regulation of circadian rhythms, including sleep-wake cycles, hormone production, and metabolism. Dysregulation of the circadian clock has been linked to various health issues, such as sleep disorders, metabolic disorders, and cancer. Therefore, studying the function and expression of PER2 can provide valuable insights into these conditions and potentially lead to the development of novel therapeutic strategies.
The PER2 Polyclonal Antibody is a reliable tool for detecting and quantifying PER2 protein levels in different cell types and tissues, making it an ideal choice for researchers investigating the circadian clock and its impact on human health. By understanding the role of PER2 in circadian regulation, researchers can contribute to the advancement of personalized medicine and chronotherapy approaches for the treatment of circadian-related disorders.
Product Name:
PER2 Rabbit Polyclonal Antibody
SKU:
CAB3217
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 390-565 of human PER2 (NP_073728.1).
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
Purification Method:
Affinity purification
Gene ID:
8864
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using PER2 Rabbit pAb (CAB3217) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
