The PER2 Polyclonal Antibody (CAB13168) is a crucial tool for researchers studying the PER2 protein, a key player in the regulation of circadian rhythms. This antibody, produced using rabbit immunization, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to PER2, this antibody enables precise detection and analysis of the protein in a variety of cell types, making it ideal for investigations in chronobiology and circadian rhythm disorders.PER2, a core component of the circadian clock, plays a vital role in regulating the body's internal clock and orchestrating daily physiological processes.
Disruptions in PER2 expression or function have been associated with a range of health issues, including sleep disorders, metabolic dysregulation, and mood disorders. By studying the function of PER2 using this antibody, researchers can gain valuable insights into the molecular mechanisms governing circadian rhythms and potentially unlock new therapeutic targets for conditions related to chronobiology.
Product Name:
PER2 Rabbit Polyclonal Antibody
SKU:
CAB13168
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 390-565 of human PER2 (NP_073728.1).
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers and have been linked to sleep disorders.
Purification Method:
Affinity purification
Gene ID:
8864
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from 293T cells, using PER2 Rabbit pAb (CAB13168) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
