Pepsinogen II (PG II) Monoclonal Antibody (CAB22282)
- SKU:
- CAB22282
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- IHC
Description
Product Name: | Pepsinogen II (PG II) Monoclonal Antibody |
SKU: | CAB22282 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-388 of human Pepsinogen II (PG II) (NP_002621.1). |
Sequence: | MKWM VVVL VCLQ LLEA AVVK VPLK KFKS IRET MKEK GLLG EFLR THKY DPAW KYRF GDLS VTYE PMAY MDAA YFGE ISIG TPPQ NFLV LFDT GSSN LWVP SVYC QSQA CTSH SRFN PSES STYS TNGQ TFSL QYGS GSLT GFFG YDTL TVQS IQVP NQEF GLSE NEPG TNFV YAQF DGIM GLAY PALS VDEA TTAM QGMV QEGA LTSP VFSV YLSN QQGS SGGA VVFG GVDS SLYT GQIY WAPV TQEL YWQI GIEE FLIG GQAS GWCS EGCQ AIVD TGTS LLTV PQQY MSAL LQAT GAQE DEYG QFLV NCNS IQNL PSLT FIIN GVEF PLPP SSYI LSNN GYCT VGVE PTYL SSQN GQPL WILG DVFL RSYY SVYD LGNN RVGF ATAA |
Tested Applications: | IHC-P ELISA |
Recommended Dilution: | IHC-P,1:50 - 1:200 |
Synonyms: | PEPC; PGII; Pepsinogen II (PG II) |
Conjugate: | Unconjugated |
Cellular Localization: | Secreted. |
Calculated MW: | 42kDa |
Observed MW: | Refer to figures |
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Purification Method: | Affinity purification |
Gene ID: | 5225 |
Clone Number: | ARC57717 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3. |