The PEMT Polyclonal Antibody (PACO47582) is a vital tool for researchers studying Phosphatidylethanolamine N-methyltransferase (PEMT), an enzyme involved in phospholipid biosynthesis. The antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it an excellent choice for Western blot applications. By binding to the PEMT protein, it allows for precise detection and analysis in a variety of cell types, making it an invaluable asset for studies in lipid metabolism and liver function.PEMT plays a crucial role in the synthesis of phosphatidylcholine, a major component of cell membranes, and is vital for maintaining lipid homeostasis in the liver.
Dysregulation of PEMT has been implicated in various liver disorders, including nonalcoholic fatty liver disease and liver cancer. By understanding the function of PEMT, researchers can gain insights into the mechanisms underlying these conditions and potentially discover new therapeutic targets for intervention.Overall, the PEMT Polyclonal Antibody is a reliable tool for investigating the role of PEMT in lipid metabolism and liver health, offering valuable insights for studies in hepatology, metabolic diseases, and cancer research.
PEMT iso2: Catalyzes three sequential methylation reactions of phosphatidylethanolamine (PE) by AdoMet, thereby producing phosphatidylcholine (PC). Belongs to the PEMT/PEM2 methyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Lipid Metabolism - glycerophospholipid; Endoplasmic reticulum; Membrane protein, multi-pass; Mitochondrial; Methyltransferase; Membrane protein, integral; EC 2.1.1.71; EC 2.1.1.17Chromosomal Location of Human Ortholog: 17p11.2Cellular Component: endoplasmic reticulum membrane; mitochondrial membrane; integral to membraneMolecular Function: phosphatidyl-N-methylethanolamine N-methyltransferase activity; phosphatidylethanolamine N-methyltransferase activityBiological Process: methylation; cell proliferation; phospholipid metabolic process; glycerophospholipid biosynthetic process; phosphatidylcholine biosynthetic process; lipid metabolic process
UniProt Protein Details:
NCBI Summary:
Phosphatidylcholine (PC) is the most abundant mammalian phospholipid. This gene encodes an enzyme which converts phosphatidylethanolamine to phosphatidylcholine by sequential methylation in the liver. Another distinct synthetic pathway in nucleated cells converts intracellular choline to phosphatidylcholine by a three-step process. The protein isoforms encoded by this gene localize to the endoplasmic reticulum and mitochondria-associated membranes. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2012]
