The PEDF Rabbit Monoclonal Antibody (CAB3475) is specifically designed for research involving Pigment Epithelium-Derived Factor (PEDF), a multifunctional protein with potent anti-angiogenic and neurotrophic properties. The antibody, raised in rabbits, shows high reactivity with human samples and is validated for use in various applications, including Western blotting.PEDF is known for its role in inhibiting tumor growth by suppressing the formation of new blood vessels, making it a promising target for cancer therapy. Additionally, PEDF has neuroprotective effects and plays a crucial role in maintaining retinal function and neuronal survival.
Understanding the mechanisms of PEDF action can provide insights into developing novel therapeutic strategies for cancer and neurodegenerative diseases.This PEDF Rabbit Monoclonal Antibody is a valuable tool for researchers studying the functions and pathways involving PEDF in various biological processes. Its specificity and sensitivity make it an ideal choice for studies in cancer research, neurobiology, and angiogenesis. By facilitating the detection and analysis of PEDF protein expression, this antibody contributes to advancing our understanding of the potential therapeutic applications of PEDF in disease treatment.
Product Name:
PEDF/SERPINF1 Rabbit Monoclonal Antibody
SKU:
CAB3475
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PEDF/SERPINF1 (P36955).
This gene encodes a member of the serpin family that does not display the serine protease inhibitory activity shown by many of the other serpin proteins. The encoded protein is secreted and strongly inhibits angiogenesis. In addition, this protein is a neurotrophic factor involved in neuronal differentiation in retinoblastoma cells. Mutations in this gene were found in individuals with osteogenesis imperfecta, type VI.
Purification Method:
Affinity purification
Gene ID:
5176
Clone Number:
ARC0784
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse liver, using PEDF/SERPINF1 Rabbit mAb (CAB3475) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
