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PEDF Monoclonal Antibody [P13D9AT] (CPAB0060)

SKU:
CPAB0060
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG1
Clone:
P13D9AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

PEDF Monoclonal Antibody [P13D9AT] (CPAB0060)

The PEDF Polyclonal Antibody (CPAB0060) is a valuable tool for researchers studying Pigment Epithelium-Derived Factor (PEDF), a multifunctional protein with diverse roles in various biological processes. The antibody, produced in rabbits, exhibits high reactivity with human, mouse, and rat samples, making it versatile for use in different model systems.PEDF is known to have anti-angiogenic, neurotrophic, and neuroprotective properties, making it a key player in the regulation of blood vessel formation, neuronal survival, and tissue homeostasis. The antibody binds specifically to PEDF, allowing for accurate detection and quantification of the protein in various experimental settings, such as Western blot and immunohistochemistry.

Research involving PEDF is relevant in the fields of ophthalmology, cancer, and neurobiology, as dysregulation of PEDF expression has been implicated in diseases like diabetic retinopathy, retinoblastoma, and neurodegenerative disorders. By utilizing the PEDF Polyclonal Antibody, scientists can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic targets for further investigation.

Product Name:PEDF Antibody
Product Sku:CPAB0060
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PEDF mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with Recombinant human PEDF protein      2-418 amino acids purified from Ecoli.
Clone:P13D9AT.
Reactivity:Human
Applications:Western Blot, ELISA
Purification Method:
Isotype:IgG1
Background:PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. PEDF is a 50,000 dalton glycoprotein created and secreted in many tissues all the way through the body. A key component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. Additionally, PEDF is capable to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuro-protective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recognition of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities associate it as a potential therapeutic agent for the treatment of vasculature related neurode
Synonyms:Pigment epithelium-derived factor, PEDF, Serpin-F1, SerpinF1, EPC-1, EPC1, PIG35.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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