The PECAM1 Polyclonal Antibody (CAB2104) is a vital tool for researchers studying Platelet Endothelial Cell Adhesion Molecule 1 (PECAM1), a protein involved in cell adhesion and signaling. This antibody, generated in rabbits, exhibits high specificity for human samples and is validated for use in Western blot applications. By binding to the PECAM1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for investigations in vascular biology and immunology.PECAM1 plays a crucial role in various physiological processes, including leukocyte trafficking, vascular remodeling, and angiogenesis. Its involvement in cellular interactions and signal transduction pathways makes it a key target for research on cardiovascular diseases, inflammation, and cancer.
Understanding the functional role of PECAM1 is essential for developing innovative therapies that target endothelial cell function and vascular health.With its high specificity and reliability, the PECAM1 Polyclonal Antibody (CAB2104) provides researchers with a valuable tool for investigating the intricate mechanisms involving PECAM1 in health and disease. By utilizing this antibody, scientists can gain valuable insights into the molecular pathways regulated by PECAM1, paving the way for advancements in therapeutic strategies targeting endothelial function and vascular disorders.
Product Name:
CD31/PECAM1 Rabbit Polyclonal Antibody
SKU:
CAB2104
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 630-738 of CD31/PECAM1 (NP_000433.4).
Cell junction, Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein.
Calculated MW:
83kDa
Observed MW:
130kDa
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Purification Method:
Affinity purification
Gene ID:
5175
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Jurkat cells, using CD31/PECAM1 antibody (CAB2104) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
