The PECAM1 Polyclonal Antibody (CAB0378) is a valuable tool for researchers studying PECAM1, also known as Platelet Endothelial Cell Adhesion Molecule 1. This cell surface protein is involved in various cellular processes, including cell adhesion, migration, and signaling. The antibody, raised in rabbits, shows high reactivity with human samples and is validated for use in Western blot applications.PECAM1 is known to play a key role in vascular biology, particularly in mediating interactions between endothelial cells and platelets. Its expression on both platelets and endothelial cells makes it a crucial player in processes like thrombosis, inflammation, and angiogenesis.
The PECAM1 Polyclonal Antibody enables precise detection and analysis of PECAM1 protein levels in different cell types, making it an essential tool for research in vascular biology, cardiovascular diseases, and inflammatory conditions.By understanding the role of PECAM1 in these physiological and pathological processes, researchers can uncover potential therapeutic targets for conditions such as atherosclerosis, stroke, and inflammatory disorders. The PECAM1 Polyclonal Antibody provides a reliable means to investigate the function and regulation of this important protein, ultimately contributing to advancements in the field of vascular research and drug development.
Product Name:
CD31/PECAM1 Rabbit Polyclonal Antibody
SKU:
CAB0378
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 630-738 of CD31/PECAM (NP_000433.4).
Cell junction, Cell junction, Cell membrane, Lipid-anchor, Single-pass type I membrane protein.
Calculated MW:
83kDa
Observed MW:
140kDa
The protein encoded by this gene is found on the surface of platelets, monocytes, neutrophils, and some types of T-cells, and makes up a large portion of endothelial cell intercellular junctions. The encoded protein is a member of the immunoglobulin superfamily and is likely involved in leukocyte migration, angiogenesis, and integrin activation.
Purification Method:
Affinity purification
Gene ID:
5175
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from THP-1 cells, using CD31/PECAM1 Rabbit pAb (CAB0378) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.