null

PEAK1 Antibody (PACO05378)

SKU:
PACO05378
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€269

Description

system_update_altDatasheetsystem_update_altMSDS

PEAK1 Antibody (PACO05378)

The Peak1 Polyclonal Antibody (PACO05378) is a valuable tool for research involving Peak1, a protein involved in cell signaling and cancer progression. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Peak1 protein, this antibody enables researchers to detect and analyze Peak1 expression in various cell types, making it ideal for studies in oncology and cell biology.Peak1, also known as p130Cas-associated protein, is a key player in signal transduction pathways that regulate cell growth, migration, and invasion.

Its involvement in cancer development and metastasis makes it a promising target for research aimed at understanding and treating malignant diseases. By studying the function of Peak1, researchers can gain insight into the mechanisms driving tumor progression and potentially identify new therapeutic strategies for combating cancer.

Antibody Name:PEAK1 Antibody (PACO05378)
Antibody SKU:PACO05378
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:5000, WB:1:500-1:2000
Species Reactivity:Human
Immunogen:Synthesized peptide derived from the N-terminal region of human SgK269.
Form:Liquid
Storage Buffer:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:PEAK1; KIAA2002; Pseudopodium-enriched atypical kinase 1; Sugen kinase 269; Tyrosine-protein kinase SgK269
UniProt Protein Function:PEAK1: a cytoskeleton-associated non-receptor tyrosine kinase that localizes to focal adhesions and actin filaments. Operates downstream of integrin and epidermal growth factor receptors, regulating the P130Cas-Crk-PXN and MAPK signaling. In the late stages of EGF signaling, SGK269 mediates Shc1 protein interactions involved in and cell spreading, migration, and morphogenesis. Amplified in a large fraction of colon cancer. Influences anchorage-independent growth and tumor progression in mice.Protein type: EC 2.7.10.2; Protein kinase, Other; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; Other group; NKF3 familyChromosomal Location of Human Ortholog: 15q24.3Cellular Component: actin cytoskeleton; cytoplasm; focal adhesion; nucleoplasm; plasma membraneMolecular Function: ATP binding; non-membrane spanning protein tyrosine kinase activity; protein bindingBiological Process: cell migration; peptidyl-tyrosine phosphorylation; protein amino acid autophosphorylation
UniProt Protein Details:
NCBI Summary:This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and cancer metastasis. [provided by RefSeq, Mar 2014]
UniProt Code:Q9H792
NCBI GenInfo Identifier:223634730
NCBI Gene ID:79834
NCBI Accession:Q9H792.4
UniProt Secondary Accession:Q9H792,Q6ZS78, Q8NAZ4, Q8NCM3, Q8TEG7
UniProt Related Accession:Q9H792
Molecular Weight:
NCBI Full Name:Pseudopodium-enriched atypical kinase 1
NCBI Synonym Full Names:pseudopodium enriched atypical kinase 1
NCBI Official Symbol:PEAK1  
NCBI Official Synonym Symbols:SGK269  
NCBI Protein Information:pseudopodium-enriched atypical kinase 1
UniProt Protein Name:Pseudopodium-enriched atypical kinase 1
UniProt Synonym Protein Names:Sugen kinase 269; Tyrosine-protein kinase SgK269
Protein Family:Pseudopodium-enriched atypical kinase
UniProt Gene Name:PEAK1  
UniProt Entry Name:PEAK1_HUMAN

Related Products