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PE/GenieFluor 594 Anti-Mouse CD8a Antibody [53-6.7] (AGEL3029)

SKU:
AGEL3029
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
53-6.7
Conjugation:
PE/AF594
€189
Frequently bought together:

Description

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PE/GenieFluor 594 Anti-Mouse CD8a Antibody [53-6.7]

The PE GenieFluor 594 Anti-Mouse CD8a Antibody (53-6.7) (AGEL3029) is a valuable tool for researchers studying CD8a, a cell surface marker predominantly found on cytotoxic T cells. This antibody, raised in mice, is highly specific for mouse samples and has been validated for use in flow cytometry and immunofluorescence applications. By binding to CD8a, this antibody enables researchers to analyze and quantify CD8a-expressing cells in various tissues and cell populations.CD8a is a crucial protein involved in immune responses, specifically in the recognition and elimination of infected or abnormal cells. Its presence on cytotoxic T cells makes it a key player in immune surveillance and defense against pathogens.

Studying CD8a expression and activity is essential for understanding immune responses in infection, cancer, and autoimmune diseases. This antibody provides researchers with a reliable tool for investigating the role of CD8a in immune regulation and disease pathology.Overall, the PE GenieFluor 594 Anti-Mouse CD8a Antibody (53-6.7) (AGEL3029) is a valuable resource for scientists interested in unraveling the complexities of immune responses and developing targeted therapies for various diseases. Its specificity and reliability make it an essential component of immunology research.

Product Title:PE/GenieFluor 594 Anti-Mouse CD8a Antibody [53-6.7]
SKU:AGEL3029
Size:25µg, 100µg
Clone No:53-6.7
Synonyms:T-cell surface glycoprotein CD8 alpha chain;CD8A;T-lymphocyte differentiation antigen T8/Leu-2;MAL;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Genie Fluor 594 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Genie Fluor594
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P01731
Gene ID:12525
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

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