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PE/GenieFluor 594 Anti-Human CD47 Antibody [CC2C6D4] (AGEL3218)

SKU:
AGEL3218
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
CC2C6D4
Conjugation:
PE/AF594
€219 - €629
Frequently bought together:

Description

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PE/GenieFluor 594 Anti-Human CD47 Antibody [CC2C6D4]

The PE-GenieFluor 594 Anti-Human CD47 Antibody (CC2C6D4) available at Assay Genie is a powerful tool for research involving CD47, a cell surface protein with essential roles in immune regulation and cancer biology. This antibody is specifically designed for detection and analysis of CD47 in human samples, providing researchers with a highly reactive and reliable tool for their experiments.CD47, also known as integrin-associated protein, is a multifunctional protein that is widely expressed on the surface of various cell types. It plays a crucial role in immune evasion and regulation of phagocytosis, making it a key player in cancer immune escape mechanisms. The PE-GenieFluor 594 Anti-Human CD47 Antibody (CC2C6D4) binds specifically to CD47, enabling researchers to study its expression and function in different cell types and biological contexts.

This antibody is validated for use in immunofluorescence and flow cytometry applications, allowing for accurate and precise detection of CD47 in experimental samples. Its high specificity and sensitivity make it an ideal choice for studies related to cancer biology, immunology, and immunotherapy research.By utilizing the PE-GenieFluor 594 Anti-Human CD47 Antibody (CC2C6D4), researchers can gain valuable insights into the role of CD47 in immune modulation, cancer progression, and therapeutic resistance. This antibody is a valuable tool for advancing our understanding of CD47 biology and developing novel strategies for cancer treatment and immunotherapy.

Product Title:PE/GenieFluor 594 Anti-Human CD47 Antibody [CC2C6D4]
SKU:AGEL3218
Size:20 Tests, 100 Tests, 200 Tests
Clone No:CC2C6D4
Synonyms:Leukocyte surface antigen CD47;Cd47;Integrin-associated protein;IAP;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Genie Fluor 594 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Genie Fluor594
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:Q08722
Gene ID:961
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD47 also known as Rh-associated protein, gp42, integrin-associated protein (IAP), and neurophilin, is a 42-52 kD member of the immunoglobulin superfamily containing a five-pass transmembrane attachment. Two splice variants have been described in the cytoplasmic tail, the shorter form is expressed in bone-marrow-derived cells, endothelial cells, and fibroblasts while the longer form is expressed by neural tissues. CD47 expression is widely distributed in hematopoietic cells including thymocytes, T cells, B cells, monocytes, platelets, and erythrocytes as well as epithelial cells, endothelial cells, fibroblasts, and neural tissues. CD47 functions as an adhesion molecule and thrombospondin receptor and is non-covalently associated with β3 integrins CD51/CD61, CD41/CD61. Thrombospondin is a ligand for CD47; in the absence of CD47 mice show defects in host defense and β3 integrin-dependent ligand binding, migration, and cellular activation. CD47 is also part of the Rh complex on erythrocytes.

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