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PE/GenieFluor 594 Anti-Human CD107a/LAMP-1 Antibody [H4A3] (AGEL3268)

SKU:
AGEL3268
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
H4A3
Conjugation:
PE/AF594
€259 - €889
Frequently bought together:

Description

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PE/GenieFluor 594 Anti-Human CD107a/LAMP-1 Antibody [H4A3]

The PE-GenieFluor 594 Anti-Human CD107a (LAMP-1) Antibody (H4A3) offered by AssayGenie is a highly specialized tool designed for researchers studying the expression and function of CD107a (LAMP-1) in human samples. This antibody, validated for use in various immunological assays, specifically binds to CD107a, a marker of lysosomal activity and degranulation in immune cells.CD107a is a critical protein involved in the process of cytotoxic granule exocytosis and is commonly used as a marker for degranulation in cytotoxic cells such as NK cells and cytotoxic T lymphocytes. By targeting CD107a, this antibody enables precise detection and analysis of degranulation events, providing valuable insights into immune cell function and immune response modulation.

With its high reactivity and specificity for human CD107a, the PE-GenieFluor 594 Anti-Human CD107a Antibody is a powerful tool for researchers in immunology, cancer research, and related fields. By accurately detecting and quantifying CD107a expression, this antibody facilitates detailed investigations into immune cell activation, function, and cytotoxicity, opening new avenues for understanding immune responses in health and disease.

Product Title:PE/GenieFluor 594 Anti-Human CD107a/LAMP-1 Antibody [H4A3]
SKU:AGEL3268
Size:20 Tests, 100 Tests, 200 Tests
Clone No:H4A3
Synonyms:Lysosome-Associated Membrane Protein 1; LGP-120; LAMP-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE/Genie Fluor 594 Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE/Genie Fluor594
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P11279
Gene ID:3916
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD107a, also known as Lysosome-Associated Membrane Protein 1 (LAMP-1) or LGP-120, is a 110-140 kD type I membrane glycoprotein. Mature CD107a is heavily glycosylated from a 40 kD core protein. This molecule is located on the luminal side of lysosomes. Upon activation, CD107a is transferred to the cell membrane surface of activated platelets, activated lymphocytes, macrophages, epithelial cells, endothelial cells, and some tumor cells. CD107a has been suggested to play a role in the protection of lysosomal membrane from lysosomal hydrolases which is involved in cell adhesion and regulation of tumor metastasis, and mediates autoimmune disease progression. CD107a is a ligand for galaptin and E-selectin. Surface expression of LAMP-1 has been shown to correlate with CD8+ T cell and NK cell cytotoxicity.

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