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PE/Cyanine7 Anti-Mouse CD272 Antibody [PK18.6] (AGEL2743)

SKU:
AGEL2743
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG1, κ
Clone:
PK18.6
Conjugation:
PE/Cyanine7
€249 - €539
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD272 Antibody [PK18.6]

The PE-Cyanine7 Anti-Mouse CD272 Antibody (PK18-6) from AssayGenie (AG-EL2743) is a powerful tool for researchers studying immune responses and immunotherapy in mouse models. This antibody specifically targets CD272, a cell surface protein involved in immune regulation and T cell activation. By using this antibody, researchers can accurately detect and analyze CD272 expression in various immune cell populations, providing valuable insights into immune responses and potential therapeutic targets. The PE-Cyanine7 conjugate allows for multi-color flow cytometry analysis, enhancing the versatility and accuracy of experimental results.

Validated for use in flow cytometry and other immunological assays, this antibody offers high specificity and sensitivity, ensuring reliable and reproducible results. Its potential applications include investigating immune checkpoint pathways, studying T cell functions, and exploring novel strategies for immunotherapy.Overall, the PE-Cyanine7 Anti-Mouse CD272 Antibody (PK18-6) is an essential tool for researchers in the fields of immunology, cancer research, and immunotherapy, enabling detailed investigations into immune regulation and potential therapeutic interventions.

Product Title:PE/Cyanine7 Anti-Mouse CD272 Antibody [PK18.6]
SKU:AGEL2743
Size:25µg, 100µg
Clone No:PK18.6
Synonyms:B- and T-lymphocyte attenuator;Btla;B- and T-lymphocyte-associated protein;CD272;Btla;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG1, κ
Isotype Control:PE/Cyanine7 Rat IgG1, κ Isotype Control[HRPN]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q7TSA3
Gene ID:208154
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD272, also known as B and T lymphocyte attenuator (BTLA), is an Ig superfamily co-inhitory receptor with structural similarity to programmed cell death 1 (PD-1) and CTLA-4. BTLA is expressed on B cells, T cells, macrophages, dendritic cells, NKT cells, and NK cells. Engagement of BTLA by its ligand herpes virus entry mediator (HVEM) is critical for negatively regulating immune response. The absence of BTLA with HVEM inhibitory interactions leads to increased experimental autoimmune encephalomyelitis severity, enhanced rejection of partially mismatched allografts, an increased CD8+ memory T cell population, increased severity of colitis, and reduced effectiveness of T regulatory cells. BTLA plays an important role in the induction of peripheral tolerance of both CD4+ and CD8+ T cells in vivo. Tolerant T cells have significantly higher expression of BTLA compared with effectors and naïve T cells. BTLA may cooperate with CTLA-4 and PD-1 to control T cell tolerance and autoimmunity. It was reported that BTLA may regulate T cell function by binding to B7-H4, but further studies are needed to confirm. The existence of three distinct BTLA alleles has been reported.

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