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PE/Cyanine7 Anti-Mouse CD206 Antibody [C068C2] (AGEL2265)

SKU:
AGEL2265
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
ICFCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
C068C2
Conjugation:
PE/Cyanine7
€249 - €619
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD206 Antibody [C068C2]

The PE-Cyanine7 Anti-Mouse CD206 Antibody (C068C2-AGEL2265) is specifically developed for research applications involving the CD206 protein, a vital cell surface marker associated with macrophages and other immune cells. This antibody, designed for use in flow cytometry and immunohistochemistry, has been rigorously tested and validated for its high specificity and sensitivity in detecting CD206 in mouse samples.CD206, also known as mannose receptor, plays a crucial role in the immune system by mediating the uptake of glycoproteins and pathogens, as well as modulating immune responses and inflammation. Its expression on macrophages is particularly relevant in the context of infectious diseases, cancer, and autoimmune disorders.

Research focusing on CD206 can provide valuable insights into the function of macrophages and their role in various disease processes.With its high reactivity and reliability in detecting CD206 in mouse samples, the PE-Cyanine7 Anti-Mouse CD206 Antibody is an essential tool for scientists studying macrophage biology, immunology, and related fields. By enabling precise detection and analysis of CD206-expressing cells, this antibody facilitates in-depth research to advance our understanding of immune responses and pathogenic mechanisms.

Product Title:PE/Cyanine7 Anti-Mouse CD206 Antibody [C068C2]
SKU:AGEL2265
Size:25µg, 100µg
Clone No:C068C2
Synonyms:MMR;MR;MRC1;macrophage mannose receptor;mannose receptor ;
Host Species:Rat
Reactivity:Mouse
Application:FCM;ICFCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q61830
Gene ID:17533
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD206, also known as mannose receptor (MR), is a 175 kD type I membrane protein. It is a pattern recognition receptor (PRR) belonging to the C-type lectin superfamily. MR is expressed on macrophages, dendritic cells, Langerhans cells, and hepatic or lymphatic endothelial cells. MR recognizes a range of microbial carbohydrates bearing mannose, fucose, or N-acetyl glucosamine through its C-type lectin-like carbohydrate recognition domains, sulfated carbohydrate antigens through its cysteine-rich domain, and collagens through its fibronectin type II domain. MR mediates endocytosis and phagocytosis as well as activation of macrophages and antigen presentation. It plays an important role in host defense and provides a link between innate and adaptive immunity. Recently, MR on lymphatic endothelial cells was found to be involved in leukocyte trafficking and a contributor to the metastatic behavior of cancer cells. It suggests that MR may be a potential target in controlling inflammation and cancer metastasis by targeting the lymphatic vasculature.

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