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PE/Cyanine7 Anti-Mouse CD200 Antibody [OX-90] (AGEL2761)

SKU:
AGEL2761
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2a, κ
Clone:
OX-90
Conjugation:
PE/Cyanine7
€249 - €579
Frequently bought together:

Description

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PE/Cyanine7 Anti-Mouse CD200 Antibody [OX-90]

The PE-Cyanine7 Anti-Mouse CD200 Antibody (OX-90) from AssayGenie (AGEL2761) is a highly specific and versatile tool for research applications involving mouse CD200, a cell surface glycoprotein known for its immunomodulatory functions. This monoclonal antibody, optimized for flow cytometry analysis, is raised in rats and exhibits exceptional sensitivity and specificity in detecting CD200 expression in mouse samples.CD200, also known as OX-2, plays a key role in immune regulation by interacting with its receptor, CD200R, to inhibit excessive immune responses and maintain immune tolerance. Research into the CD200-CD200R interaction is vital for understanding immune tolerance mechanisms and their implications in various disorders, including autoimmune diseases, transplantation, and cancer.

The PE-Cyanine7 Anti-Mouse CD200 Antibody (OX-90) offers researchers a reliable tool to study the expression and function of CD200 in diverse experimental settings, including immunology, oncology, and neuroscience research. Its high specificity and sensitivity ensure accurate and reproducible results, making it an indispensable reagent for elucidating the role of CD200 in immune regulation and disease pathogenesis.

Product Title:PE/Cyanine7 Anti-Mouse CD200 Antibody [OX-90]
SKU:AGEL2761
Size:25µg, 100µg
Clone No:OX-90
Synonyms:OX-2 membrane glycoprotein;OX-2; MRC;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2a, κ
Isotype Control:PE/Cyanine7 Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:O54901
Gene ID:4345
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD200 (OX-2 antigen) is a type-1 membrane glycoprotein containing two extracellular Ig-like domains. CD200 a highly conserved type I membrane glycoprotein that is expressed on a variety of cell types including thymocytes, some T cells, endothelial and follicular dendritc cells, B cells, and brain tissue (neurons); but not on NK cells, granulocytes, monocytes, or macrophages. CD200 costimulates T cell proliferation. It may regulate myeloid cell activity in a variety of tissues. CD200 is the ligand for CD200 receptor (CD200R). The CD200 Receptor is restricted to myeloid cells, and it is believed that its engagement with CD200 results in inhibition and/or downregulation of myeloid cell activity. Blocking of CD200/CD200R interactions decreases myeloid cell inhibitory thresholds which results in enhanced immune activation.

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