null

PE/Cyanine7 Anti-Mouse CD117 Antibody [2B8] (AGEL3052)

SKU:
AGEL3052
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Mouse
Host Species:
Rat
Isotype:
Rat IgG2b, κ
Clone:
2B8
Conjugation:
PE/Cyanine7
€159 - €409
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

PE/Cyanine7 Anti-Mouse CD117 Antibody [2B8]

The PE-Cyanine7 Anti-Mouse CD117 Antibody (2B8) is a powerful tool designed for researchers studying CD117, also known as c-kit, a key cell surface receptor involved in hematopoiesis and stem cell maintenance. This antibody, generated specifically for use in mouse samples, is ideal for flow cytometry applications and enables precise detection and analysis of CD117 expression in diverse cell populations.CD117, a receptor for stem cell factor, plays a pivotal role in the development and function of hematopoietic stem cells, mast cells, and germ cells. Its involvement in cell signaling pathways and differentiation processes makes it a crucial target for investigation in various research areas, including hematology, oncology, and regenerative medicine.

By understanding the role of CD117 in cellular function and differentiation, researchers can uncover insights into disease mechanisms and potentially develop targeted therapies for conditions such as leukemia and certain solid tumors.The PE-Cyanine7 Anti-Mouse CD117 Antibody (2B8) offers high specificity and sensitivity, allowing for reliable detection of CD117 expression levels in experimental models. With its exceptional performance and robust validation, this antibody is a valuable resource for researchers seeking to explore the biology and therapeutic potential of CD117 in a preclinical setting.

Product Title:PE/Cyanine7 Anti-Mouse CD117 Antibody [2B8]
SKU:AGEL3052
Size:25µg, 100µg
Clone No:2B8
Synonyms:Mast/stem cell growth factor receptor Kit;Kit;SCFR;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;CD117;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:PE/Cyanine7 Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P05532
Gene ID:16590
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

Related Products