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PE/Cyanine7 Anti-Human CD196/CCR6 Antibody [G034E3] (AGEL2287)

SKU:
AGEL2287
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG2b, κ
Clone:
G034E3
Conjugation:
PE/Cyanine7
$323 - $1,067
Frequently bought together:

Description

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PE/Cyanine7 Anti-Human CD196/CCR6 Antibody [G034E3]

The PE-Cyanine7 Anti-Human CD196 (CCR6) Antibody (G034E3) offered by AssayGenie is a cutting-edge tool for researchers delving into the role of CCR6, a chemokine receptor associated with immune cell migration and inflammatory processes. This antibody, optimized for use in flow cytometry, immunofluorescence, and immunohistochemistry applications, exhibits high specificity and sensitivity when detecting the CD196 protein in human samples.CCR6, a chemokine receptor functioning in the recruitment and homing of immune cells to specific tissues, plays a crucial role in various immune responses, including inflammatory and autoimmune pathways.

By targeting CCR6, researchers can gain insights into the mechanisms underlying these processes and potentially discover novel therapeutic targets for conditions involving dysregulated immune responses.The PE-Cyanine7 Anti-Human CD196 (CCR6) Antibody (G034E3) from AssayGenie presents a potent tool for investigating the intricate functions of CCR6 in health and disease, paving the way for advancements in immunology, inflammation research, and drug development.

Product Title:PE/Cyanine7 Anti-Human CD196/CCR6 Antibody [G034E3]
SKU:AGEL2287
Size:20 Tests, 100 Tests, 200 Tests
Clone No:G034E3
Synonyms:CKRL3; CMKBR6; GPR29; STRL22;GPRCY4;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:PE/Cyanine7 Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:PE/Cyanine 7
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P51684
Gene ID:1235
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CCR6, also known as CD196/CCR6, is a chemokine receptor that is expressed on immature dendritic cells, B lymphocytes, and memory T cells. CCR6 binds CCL20, although members of the β defensin family also bind CCR6 with a lower affinity. CCR6 positive cells, and its ligand CCL20, have been detected in numerous organs, especially the secondary lymphoid organ. CCL20 is selectively made by the follicle-associated epithelium (FAE) overlying Peyers Patches (PPs) and isolated lymphoid follicles (ILFs). CCL20 contributes to the recruitment of CCR6-expressing B cells to these structures. In humans, CCR6 can function to mediate arrest of T cells on dermal endothelial cells and is highly expressed on T cells resident in both normal and psoriatic skin. CCR6 and/or CCL20 have been implicated in the pathogenesis of rheumatoid arthritis and inflammatory bowel disease. Human T cells that are able to produce IL-17 express CCR6. It suggests that CCL20 and CCR6 have a role in inflammatory diseases by recruiting Th17 cells to target tissues.

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