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PE/Cyanine5 Anti-Rat CD44H Antibody [OX-49] (AGEL2434)

SKU:
AGEL2434
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Rat
Host Species:
Mouse
Isotype:
Mouse IgG2a, κ
Clone:
OX-49
Conjugation:
PE/Cyanine5
€199 - €459

Description

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PE/Cyanine5 Anti-Rat CD44H Antibody [OX-49]

The PE-Cyanine5 Anti-Rat CD44H Antibody (OX-49) is a highly specific and reliable tool for researchers studying CD44H expression in rat samples. CD44H is a cell surface glycoprotein involved in cell-cell interactions, cell adhesion, and migration, making it a key player in various physiological and pathological processes.This antibody, developed by Assay Genie, is conjugated to PE-Cyanine5, a fluorescent dye with excellent brightness and photostability, enabling precise and sensitive detection of CD44H in flow cytometry and immunofluorescence applications. With its strong reactivity towards rat CD44H, researchers can confidently analyze and quantify CD44H expression levels in different tissues and cell types.

The PE-Cyanine5 Anti-Rat CD44H Antibody (OX-49) is an essential tool for studies focusing on cell adhesion, migration, and cancer metastasis, where CD44H has been implicated in promoting tumorigenesis and invasiveness. By targeting CD44H with this antibody, researchers can gain valuable insights into the roles of CD44H in physiological and pathological conditions, ultimately advancing our understanding of cell biology and disease mechanisms.

Product Title:PE/Cyanine5 Anti-Rat CD44H Antibody [OX-49]
SKU:AGEL2434
Size:25µg, 100µg
Clone No:OX-49
Synonyms:Pgp-1; H-CAM; CD44s;CD44H;
Host Species:Mouse
Reactivity:Rat
Application:FCM
Isotype:Mouse IgG2a, κ
Isotype Control:PE/Cyanine5 Mouse IgG2a, κ Isotype Control[C1.18.4]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:P26051
Gene ID:12505
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is an 80-95 kD cell surface glycoprotein. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. It is up-regulated when T cells and B cells are activated. It was reported that CD44 is a valuable marker for memory T cells. CD44 is an adhesion molecule involved in leukocyte adhesion and homing to lymphoid organs. The OX-49 antibody reacts with CD44H (known as CD44s) expressed on most leukocytes, except for a subset of B lymphocytes. The epitope recognized by OX-49 antibody has been mapped to a region on both the standard, CD44s, and the splice variant, CD44v, isoforms of CD44. However it was reported that OX-49 antibody cannot detect the CD44V isoform, possibly due to conformational changes in the epitope.

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