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PE/Cyanine5 Anti-Human CD193/CCR3 Antibody [5E8] (AGEL3405)

SKU:
AGEL3405
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG2b, k
Clone:
[5E8]
Conjugation:
PE/Cyanine5
$311 - $1,067
Frequently bought together:

Description

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PE/Cyanine5 Anti-Human CD193/CCR3 Antibody [5E8]

The PE-Cyanine5 Anti-Human CD193 (CCR3) Antibody (5E8) is a cutting-edge tool designed for research involving the CD193 (CCR3) cell surface molecule, which is known to play a crucial role in immune responses, particularly in inflammatory and allergic conditions. This antibody, meticulously developed and rigorously validated, offers exceptional reactivity with human samples, making it an invaluable asset for a wide range of immunology studies.Expressed in rabbits and optimized for precise detection, the PE-Cyanine5 Anti-Human CD193 (CCR3) Antibody (5E8) provides researchers with a powerful means to visualize and analyze CD193 (CCR3) protein expression in various cell types. This capability facilitates detailed investigations into immune system functioning, paving the way for new insights into disease mechanisms, therapeutic targets, and potential treatment strategies.

CD193 (CCR3) is a vital component in the intricate network of immune regulation, influencing processes such as inflammation, allergy responses, and even immune cell migration. By delving into the mechanisms and functions of CD193 (CCR3), researchers can uncover key insights into conditions ranging from allergies and asthma to autoimmune disorders and chronic inflammatory diseases. This antibody serves as a key tool in the arsenal of scientists striving to unravel the complexities of immune system modulation and its impact on human health.

Product Title:PE/Cyanine5 Anti-Human CD193/CCR3 Antibody [5E8]
SKU:AGEL3405
Size:20 Tests, 100 Tests, 200 Tests
Clone No:5E8
Synonyms:CC CKR3; MIP1-alpha receptor like-2; eotaxin receptor;CCR;C-C chemokine receptor type 3;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG2b, κ
Isotype Control:PE/Cyanine5 Mouse IgG2b, κ Isotype Control[MPC-11]
Form:Liquid
Conjugation:PE/Cyanine 5
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P51677
Gene ID:1232
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD193, also known as CC-chemokine receptor 3 (CCR3), CC CKR3, MIP1-alpha receptor like-2, and eotaxin receptor, is a member of the G protein-coupled seven transmembrane receptors family. It binds to the CC chemokines eotaxin, eotaxin-2, and eotaxin-3 with high affinity. CCR3 has also been reported to bind RANTES, MCP-3, and MCP-4 with low affinity. CCR3 receptor is expressed on human eosinophils, basophils, mast cells, mononuclear phagocytes, platelets, CD34+ hematopoietic progenitor cells, Th2-like lymphocytes, and keratinocytes. CCR3 is thought to play a role in allergic diseases such as bronchial asthma and allergic rhinitis. CCR3 is a co-receptor for HIV-1 and HIV-2, and the binding of eotaxin with CCR3 has been shown to inhibit HIV infection in some cell types.

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