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PE Anti-Human MPO Antibody [ABT-101007]

SKU:
AGEL3501
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
ICFCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
ABT-101007
Conjugation:
PE
€289 - €1,109
Frequently bought together:

Description

PE Anti-Human MPO Antibody [ABT-101007]

The PE Anti-Human MPO Antibody (ABT-101007) is a powerful tool for researchers studying human myeloperoxidase (MPO), an enzyme essential for the innate immune system's antimicrobial activity. This antibody, conjugated to phycoerythrin (PE), allows for the detection and analysis of MPO in various cell types through flow cytometry and immunofluorescence applications.MPO is primarily found in neutrophils and monocytes, where it plays a crucial role in host defense by generating microbicidal reactive oxygen species. Aberrant MPO activity has been linked to various inflammatory conditions, making it a target of interest in research related to cardiovascular diseases, vasculitis, and cancer.

The PE Anti-Human MPO Antibody provides researchers with a specific and sensitive tool to explore MPO expression and regulation in both healthy and diseased states.This antibody, rigorously validated for its specificity and sensitivity to human MPO, offers researchers the opportunity to deepen their understanding of the enzyme's functions and dysregulation in disease contexts. Its versatility in flow cytometry and immunofluorescence applications makes it an invaluable asset for studies focused on immune system modulation, inflammation, and oxidative stress.

Product Name:PE Anti-Human MPO Antibody [ABT-101007]
Product Code:AGEL3501
Size:20 Tests, 100 Tests, 200 Tests
Clone No:ABT-101007
Synonyms:Myeloperoxidase
Reactivity:Human
Host Species:Mouse
Applications:ICFCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control [MOPC-21]
Conjugation:PE
Applications:ICFCM
Recommended Dilution:Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Storage:Keep as concentrated solution. Store at 2-8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Fluorescent Label:PE is designed to be excited by the Blue (488 nm), Green (532 nm) and Yellow-Green (561 nm) lasers and detected using an optical filter centered near 575 nm (e.g., a 585/42 nm bandpass filter).
Shipping:Biological ice pack at 4°C
Form:Liquid
Gene ID:4353
Swissprot:P05164
Background Information:Myeloperoxidase (MPO) is a heterotetrameric protein consisting of two 60 kD heavy units and two 12 kD light units. A lysosomal enzyme, MPO is able to catalyze the production of hypochlorous acid, a potent microbicidal agent, from hydrogen peroxide and chloride anion during the neutrophil respiratory burst. MPO is a major enzyme involved in the inflammatory responses of polymorphonuclear leucocytes. MPO is localized to the azurophilic granules of mature granulocytes and monocytes and is also expressed in some acute myeloid leukemia cells.

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