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PE Anti-Human/Mouse KLRG-1 Antibody [2F1] (AGEL3131)

SKU:
AGEL3131
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Mouse
Host Species:
Syrian Hamster
Isotype:
Syrian Hamster IgG
Clone:
2F1
Conjugation:
PE
€199 - €479
Frequently bought together:

Description

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PE Anti-Human/Mouse KLRG-1 Antibody [2F1]

The Mouse KLRG1 Monoclonal Antibody (2F1) is a specialized tool for research involving the KLRG1 protein, a marker associated with immune cell differentiation and function. This monoclonal antibody, specifically targeting the human and mouse KLRG1 protein, is generated for use in various experimental applications. Its reactivity with human and mouse samples allows for versatile research applications, particularly in immunology and cell biology studies.KLRG1, also known as killer cell lectin-like receptor subfamily G member 1, is a cell surface receptor expressed on specific immune cell subsets, including cytotoxic T cells and natural killer cells. Its role in immune cell differentiation and function implicates KLRG1 in immune responses, including anti-viral and anti-tumor activities.

Research into the regulation and impact of KLRG1 expression can provide valuable insights into immune cell behavior and may have implications for therapeutic strategies targeting immune-mediated diseases and cancer.This 2F1 monoclonal antibody enables precise detection and analysis of the KLRG1 protein in various cell types, offering researchers a reliable tool to investigate the role of KLRG1 in immune responses and disease pathogenesis. Validated for use in multiple experimental techniques, including immunofluorescence and flow cytometry, this antibody is a valuable asset for studies aiming to unravel the complexities of immune cell biology and its relevance to health and disease.

Product Title:PE Anti-Human/Mouse KLRG-1 Antibody [2F1]
SKU:AGEL3131
Size:25µg, 100µg
Clone No:2F1
Synonyms:MAFA; 2F1-Ag;
Host Species:Syrian Hamster
Reactivity:Human;Mouse
Application:FCM
Isotype:Syrian Hamster IgG
Isotype Control:PE Syrian Hamster IgG Isotype Control[SHG-1]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use. We suggest each investigator should titrate the reagent to obtain optimal results [The recommended concentration is 0.1-1 μg/106 cells in 100 μL volume].
Spectrum:Spectrum Image
Swissprot:Q96E93 O88713
Gene ID:10219,50928
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Killer cell lectin-like receptor G1 (KLRG1) is the mouse homolog of the rat mast cell function-associated antigen (MAFA or 2F1-Ag). KLRG1 is a type II membrane glycoprotein that was first identified on the surface of rat mast cell line RBL-2H3. It is composed of a homodimer of glycosylated 30-38 kD subunits. Mouse and human homologs of KLRG1 are expressed by subsets of NK cells and lymphokine-activated killer (LAK) cells but not mast cells. KLRG1 is also expressed on subsets of CD8+ and CD4+ cells, including CD4+ and CD8+ effector/memory cells, potent regulatory CD4+ T cells. KLRG1 may be involved in regulating NK cell homeostasis. KLRG21 was found to recognize cadherins and thus inhibit immune responses by regulating the effector function and the developmental processes of NK and T cells.

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