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PE Anti-Human CD22 Antibody [HIB22] (AGEL3437)

SKU:
AGEL3437
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Applications:
FCM
Reactivity:
Human
Host Species:
Mouse
Isotype:
Mouse IgG1, k
Clone:
HIB22
Conjugation:
PE
€169 - €629
Frequently bought together:

Description

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PE Anti-Human CD22 Antibody [HIB22]

The PE Anti-Human CD22 Antibody (HIB22) available at www.assaygenie.com/pe-anti-human-cd22-antibody-hib22/ is a valuable tool for researchers studying CD22, a cell surface protein predominantly found on B cells and involved in B cell signaling and activation. This monoclonal antibody is specifically designed for use in flow cytometry applications, providing researchers with a reliable means of identifying and analyzing CD22-expressing cells in various samples.CD22 is known for its role in B cell development, activation, and tolerance, making it a key target for investigation in immunology and related fields. By utilizing the PE Anti-Human CD22 Antibody (HIB22), researchers can gain insights into the expression levels and distribution of CD22 on different cell populations, contributing to a better understanding of B cell function and dysregulation in diseases such as leukemia, lymphoma, and autoimmune disorders.

With its high specificity and sensitivity, this antibody enables precise detection and quantification of CD22, paving the way for advancements in basic research, drug development, and diagnostic applications related to B cell biology and associated pathologies. Researchers can rely on the PE Anti-Human CD22 Antibody (HIB22) to enhance their studies and drive new discoveries in the field of immunology.

Product Title:PE Anti-Human CD22 Antibody [HIB22]
SKU:AGEL3437
Size:20 Tests, 100 Tests, 200 Tests
Clone No:HIB22
Synonyms:B-cell receptor CD22;Cd22;B-lymphocyte cell adhesion molecule;BL-CAM;Sialic acid-binding Ig-like lectin 2;Siglec-2;T-cell surface antigen Leu-14;CD22;Lyb-8; Siglec2;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:PE Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:PE
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 µL of antibody per test (million cells in 100 µL staining volume or per 100 µL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.
Spectrum:Spectrum Image
Swissprot:P20273
Gene ID:933
Storage Buffer:Phosphate buffered solution, pH 7.2, containing 0.09% stabilizer and 1% protein protectant.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.

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