The PDZK1 Polyclonal Antibody (CAB5321) is a valuable tool for researchers studying the PDZK1 protein, known for its role in regulating the function of membrane transport proteins in the kidneys, liver, and intestines. This antibody is raised in rabbits and is highly reactive with human samples, making it ideal for use in Western blot applications.PDZK1 plays a critical role in mediating the transport and localization of various proteins involved in lipid and cholesterol metabolism, making it an important target for studies in metabolic disorders and cardiovascular diseases.
By detecting and analyzing PDZK1 protein levels in different cell types, researchers can gain insights into its function and potential therapeutic applications.The validation of this antibody for Western blot applications ensures reliable and accurate results for research in areas such as lipid metabolism, cholesterol transport, and renal function. Its specificity to PDZK1 makes it a valuable tool for investigating the molecular mechanisms underlying these processes and developing targeted therapies for related diseases.
Product Name:
PDZK1 Rabbit Polyclonal Antibody
SKU:
CAB5321
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human PDZK1 (NP_001188254.1).
This gene encodes a PDZ domain-containing scaffolding protein. PDZ domain-containing molecules bind to and mediate the subcellular localization of target proteins. The encoded protein mediates the localization of cell surface proteins and plays a critical role in cholesterol metabolism by regulating the HDL receptor, scavenger receptor class B type 1. Single nucleotide polymorphisms in this gene may be associated with metabolic syndrome, and overexpression of this gene may play a role in drug resistance of multiple myeloma. Pseudogenes of this gene are located on the long arm of chromosome 1. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
5174
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PDZK1 antibody (CAB5321) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
