null

Pdxp Antibody (PACO53714)

SKU:
PACO53714
Product Type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

system_update_altDatasheetsystem_update_altMSDS

Pdxp Antibody (PACO53714)

The PDXP Polyclonal Antibody (PAC053714) is a valuable tool for researchers studying the pyridoxal phosphate phosphatase (PDXP) protein, which is involved in the metabolism of vitamin B6. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.The PDXP protein plays a crucial role in the regulation of vitamin B6 levels in cells, making it essential for various cellular processes such as amino acid metabolism, neurotransmitter synthesis, and immune function. Dysregulation of PDXP has been associated with diseases like epilepsy, Parkinson's disease, and certain types of cancer, highlighting its importance in health and disease.

By using the PDXP Polyclonal Antibody, researchers can detect and analyze the expression of PDXP in different cell types, providing valuable insights into its function and potential implications in various pathological conditions. This antibody is a valuable tool for studies in biochemistry, neurology, and cancer research, offering new avenues for understanding the role of PDXP in human health.

Antibody Name:Pdxp Antibody (PACO53714)
Antibody SKU:PACO53714
Size:50ug
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Mouse, Rat
Immunogen:Recombinant Mouse Pyridoxal phosphate phosphatase protein (1-292AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Rat brain tissue. All lanes: Pdxp antibody at 2.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 32 kDa. Observed band size: 32 kDa.
Background:Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis (By similarity). Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP.
Synonyms:Pyridoxal phosphate phosphatase (PLP phosphatase) (EC 3.1.3.3) (EC 3.1.3.74) (Chronophin), Pdxp, Cin Plp Plpp
UniProt Protein Function:PDXP: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho- tyrosine. Pyridoxal phosphate phosphatase. Has some activity towards pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PMP) and pyridoxine 5'-phosphate (PNP), with a highest activity with PLP followed by PNP. Homodimer. Ubiquitous. Highly expressed in all the regions of central nerve system except the spinal cord. Also expressed at high level in liver and testis. In fetus, it is weakly expressed in all organs except brain. Inhibited by NaF, Zn(2+), Ca(2+), Mn(2+) and EDTA. Belongs to the HAD-like hydrolase superfamily.Protein type: Cofactor and Vitamin Metabolism - vitamin B6; EC 3.1.3.74; Cell cycle regulation; EC 3.1.3.3; Protein phosphatase, Ser/Thr (non-receptor)Cellular Component: lamellipodium; plasma membrane; intercellular junction; midbody; cytosol; cleavage furrow; actin cytoskeletonMolecular Function: heat shock protein binding; phosphoprotein phosphatase activityBiological Process: actin rod formation; positive regulation of actin filament depolymerization; regulation of mitosis; protein amino acid dephosphorylation; regulation of cytokinesis
UniProt Protein Details:
NCBI Summary:
UniProt Code:P60487
NCBI GenInfo Identifier:47059486
NCBI Gene ID:57028
NCBI Accession:NP_064667.2
UniProt Secondary Accession:P60487
UniProt Related Accession:P60487
Molecular Weight:33.5 kDa
NCBI Full Name:pyridoxal phosphate phosphatase
NCBI Synonym Full Names:pyridoxal (pyridoxine, vitamin B6) phosphatase
NCBI Official Symbol:Pdxp  
NCBI Official Synonym Symbols:PLPP; AB041662; 1600027H05Rik  
NCBI Protein Information:pyridoxal phosphate phosphatase; chronophin; chronophilin; PLP phosphatase; PLP-phosophatase
UniProt Protein Name:Pyridoxal phosphate phosphatase
UniProt Synonym Protein Names:Chronophin
Protein Family:Pyridoxal phosphate phosphatase
UniProt Gene Name:Pdxp  
UniProt Entry Name:PLPP_MOUSE
ELISA Kits
Mouse Pyridoxal phosphate phosphatase (Pdxp) ELISA Kit
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
Recommended Products
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011)
Anti-HRP-conjugated Beta Actin Antibody (CABC028)

Related Products