The PDXK Polyclonal Antibody (CAB24034) is a valuable tool for researchers studying the PDXK protein, an essential enzyme involved in vitamin B6 metabolism. This antibody, generated in rabbits, is highly specific to human samples and is validated for use in Western blot applications. By binding to the PDXK protein, this antibody enables the detection and analysis of PDXK in various cell types, making it ideal for studies in biochemistry, metabolism, and cancer research.PDXK is a key player in vitamin B6 metabolism, converting pyridoxine (vitamin B6) into its active form, pyridoxal phosphate. This process is crucial for a variety of cellular functions, including amino acid metabolism, neurotransmitter synthesis, and DNA synthesis.
Dysregulation of PDXK has been linked to diseases such as cancer, cardiovascular disorders, and neurodegenerative diseases, making it an important target for further research.By using the PDXK Polyclonal Antibody (CAB24034), researchers can gain insights into the role of PDXK in normal cellular function and disease states. Understanding the mechanisms of PDXK activity may lead to the development of new therapeutic strategies for treating conditions associated with vitamin B6 metabolism dysregulation.
Product Name:
PDXK Polyclonal Antibody
SKU:
CAB24034
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 213-312 of human PDXK (NP_003672.1).
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
8566
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KD Validated]PDXK Rabbit pAb (CAB24034) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
