The PDXK Polyclonal Antibody (CAB21693) is a valuable tool for researchers studying PDXK, an enzyme involved in the phosphorylation of pyridoxine (vitamin B6) to pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in various applications, including Western blot and immunohistochemistry.PDXK plays a crucial role in vitamin B6 metabolism and is essential for the synthesis of neurotransmitters, amino acids, and other important molecules in the body. Dysregulation of PDXK has been implicated in various diseases, including neurological disorders, metabolic disorders, and cancers.
By targeting PDXK, researchers can gain insights into the role of vitamin B6 in health and disease, leading to the development of new therapeutic strategies.This antibody enables precise detection and visualization of PDXK in different cell types and tissues, making it an ideal choice for studies in biochemistry, metabolism, and cancer biology. By studying the function and regulation of PDXK, researchers can uncover new pathways for potential therapeutic interventions and improve our understanding of the role of vitamin B6 in human health.
Product Name:
PDXK Polyclonal Antibody
SKU:
CAB21693
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-312 of human PDXK (NP_003672.1).
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
8566
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts from normal (control) and PDXK knockout (KO) 293T cells, using PDXK antibody (CAB21693) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
