The Pyridoxal Kinase Polyclonal Antibody (CAB6687) is a valuable tool for researchers studying pyridoxal kinase, an essential enzyme involved in vitamin B6 metabolism. This antibody, generated in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the pyridoxal kinase protein, researchers can detect and analyze its expression in various cell types, offering valuable insights into its role in cellular processes related to vitamin B6 metabolism.Pyridoxal kinase is crucial for converting pyridoxal (a form of vitamin B6) into its active form, pyridoxal 5'-phosphate, which is involved in a wide range of biochemical reactions in the body.
Dysregulation of pyridoxal kinase activity has been linked to various health conditions, such as neurological disorders, cardiovascular diseases, and metabolic disorders. Therefore, understanding the function of pyridoxal kinase is essential for developing potential therapies targeting these conditions.By utilizing the Pyridoxal Kinase Polyclonal Antibody (CAB6687), researchers can further explore the role of pyridoxal kinase in health and disease, paving the way for advancements in the fields of biochemistry, nutrition, and personalized medicine.
Product Name:
PDXK Rabbit Polyclonal Antibody
SKU:
CAB6687
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-312 of human PDXK (NP_003672.1).
The protein encoded by this gene phosphorylates vitamin B6, a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. The encoded protein is cytoplasmic and probably acts as a homodimer. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.
Purification Method:
Affinity purification
Gene ID:
8566
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PDXK antibody (CAB6687) at 1:600 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
