The PDX1 Polyclonal Antibody (CAB3070) is a valuable tool for researchers studying PDX1, a transcription factor crucial for pancreatic development and beta cell function. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By targeting the PDX1 protein, this antibody allows for the detection and analysis of PDX1 expression in various cell types, making it an ideal choice for research in pancreatic biology and diabetes.
PDX1 plays a key role in regulating the development and function of pancreatic beta cells, making it a promising target for studies on diabetes and other metabolic disorders. Understanding the expression and function of PDX1 is essential for uncovering its mechanisms in pancreatic development and beta cell maintenance. The PDX1 Polyclonal Antibody is a valuable tool for researchers seeking to further explore the role of PDX1 in health and disease.
Product Name:
PDX1 Rabbit Polyclonal Antibody
SKU:
CAB3070
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDX1 (P52945).
The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4).
Purification Method:
Affinity purification
Gene ID:
3651
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse intestine, using PDX1 Rabbit pAb (CAB3070) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
