The PDPN Polyclonal Antibody (CAB13261) is a valuable tool for researchers studying podoplanin, a glycoprotein involved in various biological processes such as cell migration, platelet aggregation, and tumor progression. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in techniques such as immunohistochemistry, immunofluorescence, and flow cytometry.Podoplanin is commonly overexpressed in cancer cells, particularly in squamous cell carcinomas, making it a potential target for cancer therapy development. The PDPN Polyclonal Antibody binds specifically to podoplanin, enabling precise detection and analysis in different tissues and cell types.
Its application in research on tumor biology, metastasis, and angiogenesis underscores its importance in advancing our understanding of cancer progression and potential treatment strategies.By providing researchers with a reliable and sensitive tool for studying podoplanin, the PDPN Polyclonal Antibody (CAB13261) facilitates investigations into the role of this glycoprotein in cancer and other diseases, ultimately contributing to the development of novel therapeutic approaches targeting podoplanin pathways.
Product Name:
Podoplanin Rabbit Polyclonal Antibody
SKU:
CAB13261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 23-131 of human Podoplanin (NP_006465.3).
Sequence:
ASTG QPED DTET TGLE GGVA MPGA EDDV VTPG TSED RYKS GLTT LVAT SVNS VTGI RIED LPTS ESTV HAQE QSPS ATAS NVAT SHST EKVD GDTQ TTVE KDGL STVT L
Cell projection, Membrane, Single-pass type I membrane protein, filopodium membrane, lamellipodium membrane, microvillus membrane, ruffle membrane.
Calculated MW:
17kDa
Observed MW:
36kDa
This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
10630
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using Podoplanin Rabbit pAb (CAB13261) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
