PDPN Antibody (PACO20912)
- SKU:
- PACO20912
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
PDPN Antibody (PACO20912)
The PDPN Polyclonal Antibody (PAC020912) is a valuable tool for researchers studying podoplanin, a glycoprotein involved in various physiological and pathological processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is validated for use in Western blot applications. By binding to the PDPN protein, this antibody allows for precise detection and analysis in different cell types, making it an ideal choice for investigations in cancer research and immunology.Podoplanin, also known as T1α, plays a crucial role in cell adhesion, migration, and tumor progression. Its expression is often associated with aggressive features in cancer cells, making it a promising target for therapeutic interventions.
Understanding the function and regulation of podoplanin can provide valuable insights into tumor biology and potentially lead to the development of novel cancer treatments.In conclusion, the PDPN Polyclonal Antibody is a reliable tool for studying podoplanin and its role in cancer and other diseases. Its high reactivity and specificity make it a valuable asset for researchers looking to advance their understanding of podoplanin biology and its implications in various pathological conditions.
| Antibody Name: | PDPN Antibody (PACO20912) |
| Antibody SKU: | PACO20912 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:10-1:50 |
| Species Reactivity: | Human |
| Immunogen: | Synthetic peptide of human PDPN |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using PACO20912(PDPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-2: 293T cells, Hela cells,Primary antibody: PACO20912(PDPN Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 2 minutes. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20912(PDPN Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. |
| Synonyms: | podoplanin |
| UniProt Protein Function: | PDPN: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 1p36.21 Cellular Component: external side of plasma membrane; filopodium; filopodium membrane; integral to plasma membrane; lamellipodium; microvillus membrane; plasma membrane; ruffle Molecular Function:amino acid transmembrane transporter activity; folic acid transporter activity; water channel activity; water transporter activity Biological Process: alveolus development; amino acid transport; cell morphogenesis; cell motility involved in cell locomotion; cell proliferation; cell-cell adhesion; folic acid transport; lung development; lymphangiogenesis; platelet activation; positive regulation of cell motility; prostaglandin metabolic process; regulation of cell shape; signal transduction; water transport |
| NCBI Summary: | This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q86YL7 |
| NCBI GenInfo Identifier: | 215274223 |
| NCBI Gene ID: | 10630 |
| NCBI Accession: | Q86YL7.3 |
| UniProt Secondary Accession: | Q86YL7,O60836, O95128, Q7L375, Q8NBQ8, Q8NBR3, A9Z1Y2 B2R6J8, E9PB68, F6QWX5, |
| UniProt Related Accession: | Q86YL7 |
| Molecular Weight: | 12,421 Da |
| NCBI Full Name: | Podoplanin |
| NCBI Synonym Full Names: | podoplanin |
| NCBI Official Symbol: | PDPNÂ Â |
| NCBI Official Synonym Symbols: | T1A; GP36; GP40; Gp38; OTS8; T1A2; TI1A; T1A-2; AGGRUS; HT1A-1; PA2.26Â Â |
| NCBI Protein Information: | podoplanin |
| UniProt Protein Name: | Podoplanin |
| UniProt Synonym Protein Names: | Aggrus; Glycoprotein 36; Gp36; PA2.26 antigen; T1-alpha; T1A |
| Protein Family: | Podoplanin |
| UniProt Gene Name: | PDPNÂ Â |
| UniProt Entry Name: | PDPN_HUMAN |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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