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PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)

SKU:
CPAB0527
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P5E2AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

PDPN Monoclonal Antibody [P5E2AT] (CPAB0527)

The PDPN Polyclonal Antibody (CPAB0527) is a valuable tool for researchers studying PDPN, a cell surface protein involved in various biological processes, including cell migration, adhesion, and proliferation. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples and is optimized for Western blot applications.PDPN, also known as podoplanin, is a marker for lymphatic endothelial cells and cancer stem cells, making it a key target in cancer research. Its role in tumor progression and metastasis has sparked interest in developing targeted therapies for various types of cancer.

By enabling the detection and analysis of PDPN in different cell types, this antibody provides researchers with a reliable means to investigate the function and significance of this protein in cancer biology.Furthermore, PDPN has been implicated in inflammation and lymphangiogenesis, suggesting its potential relevance in immune responses and vascular development. The ability to study PDPN expression and localization using this antibody opens up opportunities for exploring its involvement in other physiological and pathological processes, offering insights that may lead to novel therapeutic strategies.

Product Name:PDPN Antibody
Product Sku:CPAB0527
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PDPN mAb is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human PDPN amino acids 1-26 purified from Ecoli.
Clone:P5E2AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:PDPN antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Podoplanin is a small mucin-like type-1 transmembrane protein, typically expressed in various specialized cell types throughout the body. Podoplanin is a type-I integral membrane glycoprotein with diverse distribution in human tissues. PDPN physiological function is related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. PDPN is expressed in lymphatic progenitor cells and afterwards during mouse development in lymphatic endothelial cells. Podoplanin is a specific marker for lymph vessel endothelial cells. Over-expression of podoplanin significantly elevates endothelial cell adhesion, migration, and tube formation. Inhibition of Podoplanin expression decreases cell adhesion in human dermal lymphatic endothelial cells. Podoplanin is used as a specific marker for lymphatic endothelium in histopathology. Podoplanin expression is increased in nearly all human colon, rectum, and small intestine tumors. AGGRUS may serve as a diagnostic marker that distinguishes seminomas, the majority of which over express the protein, from embryonal carcinoma in testicular germ cell tumors.
Synonyms:Podoplanin, Glycoprotein 36, PA2.26 antigen, T1A, GP36, GP40, Gp38, OTS8, T1A2, HT1A-1, PA2.26, T1-alpha, PDPN.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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