The PDP1 Polyclonal Antibody (CAB6332) is a valuable tool for researchers studying PDP1, a key protein involved in regulating immune responses. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It targets the PDP1 protein, allowing for accurate detection and analysis in a variety of cell types, making it essential for studies in immunology and cancer research.PDP1, also known as immune modulatory protein, plays a crucial role in fine-tuning immune responses by regulating inflammatory processes and modulating immune cell function.
Its importance in immune regulation makes it an attractive target for research on diseases such as cancer, autoimmune disorders, and chronic inflammatory conditions. Understanding the role of PDP1 is essential for developing targeted therapies that can manipulate immune responses in these disease contexts.
Product Name:
PDP1 Rabbit Polyclonal Antibody
SKU:
CAB6332
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 278-537 of human PDP1 (NP_060914.2).
Pyruvate dehydrogenase (E1) is one of the three components (E1, E2, and E3) of the large pyruvate dehydrogenase complex. Pyruvate dehydrogenase kinases catalyze phosphorylation of serine residues of E1 to inactivate the E1 component and inhibit the complex. Pyruvate dehydrogenase phosphatases catalyze the dephosphorylation and activation of the E1 component to reverse the effects of pyruvate dehydrogenase kinases. Pyruvate dehydrogenase phosphatase is a heterodimer consisting of catalytic and regulatory subunits. Two catalytic subunits have been reported; one is predominantly expressed in skeletal muscle and another one is is much more abundant in the liver. The catalytic subunit, encoded by this gene, is the former, and belongs to the protein phosphatase 2C (PP2C) superfamily. Along with the pyruvate dehydrogenase complex and pyruvate dehydrogenase kinases, this enzyme is located in the mitochondrial matrix. Mutation in this gene causes pyruvate dehydrogenase phosphatase deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified.
Purification Method:
Affinity purification
Gene ID:
54704
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDP1 Rabbit pAb (CAB6332) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
