The PDLIM3 Polyclonal Antibody (CAB6346) is a valuable tool for researchers studying PDLIM3, a protein involved in various cellular processes including cell growth, differentiation, and cytoskeletal organization. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards PDLIM3 in human samples, making it suitable for Western blot applications.PDLIM3, also known as PDZ and LIM domain protein 3, plays a crucial role in regulating intracellular signaling pathways and protein-protein interactions. Its significance in cell physiology and pathology makes it a target of interest in cancer research, cardiovascular diseases, and neurological disorders.
By utilizing the PDLIM3 Polyclonal Antibody, researchers can accurately detect and analyze PDLIM3 expression in different cell types, aiding in the understanding of its function and potential therapeutic implications.Overall, the PDLIM3 Polyclonal Antibody is a reliable tool for investigating the roles of PDLIM3 in various biological processes and diseases, ultimately contributing to advancements in biomedical research and drug development.
Product Name:
PDLIM3 Rabbit Polyclonal Antibody
SKU:
CAB6346
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 70-230 of human PDLIM3 (NP_001107579.1).
The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.
Purification Method:
Affinity purification
Gene ID:
27295
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of mouse lung, using PDLIM3 antibody (CAB6346) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
