The PDLIM2 Polyclonal Antibody (PAC052714) is a valuable tool for researchers studying the PDLIM2 protein, which is involved in various cellular processes including cell adhesion, migration, and signal transduction. This antibody, generated in rabbits, exhibits high specificity towards human samples and is validated for use in Western blot applications.PDLIM2, also known as PDZ and LIM domain protein 2, is a versatile protein that interacts with multiple binding partners to regulate cell functions. Its involvement in cell signaling pathways and cytoskeletal organization makes it a key player in processes like cell migration and differentiation.
By targeting PDLIM2 with this antibody, researchers can detect and analyze its expression levels in different cell types, providing valuable insights into its role in various physiological and pathological conditions.With its potential implications in cancer, cardiovascular diseases, and neurological disorders, studying PDLIM2 is essential for understanding disease mechanisms and identifying therapeutic targets. The PDLIM2 Polyclonal Antibody enables researchers to further explore the functions of this protein, ultimately contributing to advancements in biomedicine and drug development.
Antibody Name:
PDLIM2 Antibody (PACO52714)
Antibody SKU:
PACO52714
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, IHC
Recommended Dilutions:
ELISA:1:2000-1:10000, IHC:1:20-1:200
Species Reactivity:
Human
Immunogen:
Recombinant Human PDZ and LIM domain protein 2 protein (161-284AA)
Immunohistochemistry of paraffin-embedded human tonsil tissue using PACO52714 at dilution of 1:100.
Immunohistochemistry of paraffin-embedded human kidney tissue using PACO52714 at dilution of 1:100.
Background:
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity.
Synonyms:
PDZ and LIM domain protein 2 (PDZ-LIM protein mystique), PDLIM2
UniProt Protein Function:
PDLIM2: Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity. Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. 4 isoforms of the human protein are produced by alternative splicing.Protein type: Ubiquitin ligase; Cell adhesionChromosomal Location of Human Ortholog: 8p21.3Cellular Component: cortical actin cytoskeleton; focal adhesion; stress fiber; nucleus; actin cytoskeletonMolecular Function: zinc ion binding; filamin binding; muscle alpha-actinin binding; myosin heavy chain binding
UniProt Protein Details:
NCBI Summary:
This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
