PDK3 Rabbit Polyclonal Antibody (CAB12480)
- SKU:
- CAB12480
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
Product Name: | PDK3 Rabbit Polyclonal Antibody |
SKU: | CAB12480 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 137-406 of human PDK3 (NP_005382.1). |
Sequence: | FGFD PFIS TNIQ YFLD RFYT NRIS FRML INQH TLLF GGDT NPVH PKHI GSID PTCN VADV VKDA YETA KMLC EQYY LVAP ELEV EEFN AKAP DKPI QVVY VPSH LFHM LFEL FKNS MRAT VELY EDRK EGYP AVKT LVTL GKED LSIK ISDL GGGV PLRK IDRL FNYM YSTA PRPS LEPT RAAP LAGF GYGL PISR LYAR YFQG DLKL YSME GVGT DAVI YLKA LSSE SFER LPVF NKSA WRHY KTTP EADD WSNP SSEP RDAS KYKA KQ |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 |
Synonyms: | CMTX6; GS1-358P8.4; PDK3 |
Positive Sample: | SH-SY5Y |
Conjugate: | Unconjugated |
Cellular Localization: | Mitochondrion matrix. |
Calculated MW: | 47kDa |
Observed MW: | 47kDa |
The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle, and thus is one of the major enzymes responsible for the regulation of glucose metabolism. The enzymatic activity of PDH is regulated by a phosphorylation/dephosphorylation cycle, and phosphorylation results in inactivation of PDH. The protein encoded by this gene is one of the three pyruvate dehydrogenase kinases that inhibits the PDH complex by phosphorylation of the E1 alpha subunit. This gene is predominantly expressed in the heart and skeletal muscles. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method: | Affinity purification |
Gene ID: | 5165 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |