The PDK1 Rabbit Monoclonal Antibody (CAB8930) is a powerful tool for researchers studying the protein kinase PDK1, a key regulator of cell growth, metabolism, and survival. This antibody, developed using rabbit monoclonal technology, is highly specific and sensitive for detecting PDK1 in a variety of samples, making it ideal for use in Western blot and immunohistochemistry applications.PDK1 plays a crucial role in signaling pathways involved in cell proliferation, differentiation, and survival. Dysregulation of PDK1 activity has been implicated in various diseases, including cancer, diabetes, and neurodegenerative disorders.
By targeting PDK1 with this monoclonal antibody, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.With its high affinity and specificity, the PDK1 Rabbit Monoclonal Antibody (CAB8930) is a reliable tool for investigating the function and regulation of PDK1 in biological processes. Its versatility and ease of use make it a valuable asset for studies in cell biology, biochemistry, and drug discovery, paving the way for advancements in our understanding of PDK1 and its implications for human health.
Product Name:
PDK1 Rabbit Monoclonal Antibody
SKU:
CAB8930
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 337-436 of human PDK1/PDHK1 (NP_002601.1).
Pyruvate dehydrogenase (PDH) is a mitochondrial multienzyme complex that catalyzes the oxidative decarboxylation of pyruvate and is one of the major enzymes responsible for the regulation of homeostasis of carbohydrate fuels in mammals. The enzymatic activity is regulated by a phosphorylation/dephosphorylation cycle. Phosphorylation of PDH by a specific pyruvate dehydrogenase kinase (PDK) results in inactivation. Multiple alternatively spliced transcript variants have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
5163
Clone Number:
ARC52376
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates, using PDK1/PDHK1 Rabbit mAb (CAB8930) at 1:20000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
