The PDIA6 Rabbit Monoclonal Antibody (CAB4260) is a cutting-edge tool for researchers studying PDIA6, a protein involved in protein folding and regulation of redox homeostasis in the endoplasmic reticulum. This antibody, produced using rabbit monoclonal technology, provides high specificity and sensitivity in detecting PDIA6 in human samples, making it a reliable choice for Western blot applications.PDIA6, also known as P5, is a multifunctional protein that plays a crucial role in maintaining cellular protein quality control and redox balance. Dysregulation of PDIA6 has been linked to various diseases, including cancer, neurodegenerative disorders, and diabetes, making it a promising target for therapeutic interventions.
Understanding the function and regulation of PDIA6 is essential for uncovering its role in disease pathogenesis and developing novel treatments.By utilizing the PDIA6 Rabbit Monoclonal Antibody (CAB4260), researchers can delve deeper into the mechanisms underlying PDIA6-mediated processes and elucidate its potential as a therapeutic target. This antibody empowers reliable and accurate detection of PDIA6 in various cell types, offering valuable insights into its function and implications in disease biology. Whether investigating protein folding pathways or exploring redox signaling mechanisms, this antibody is a valuable tool for advancing research in molecular biology and biomedical sciences.
Product Name:
PDIA6 Rabbit Monoclonal Antibody
SKU:
CAB4260
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PDIA6 (NP_005733.1).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10130
Clone Number:
ARC0944
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using PDIA6 Rabbit mAb (CAB4260) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
