The PDIA6 Polyclonal Antibody (CAB7055) is a valuable tool for researchers studying PDIA6, a protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. It binds specifically to the PDIA6 protein, allowing for the detection and analysis of this important cellular component in a variety of cell types.PDIA6, also known as protein disulfide isomerase family A member 6, is essential for maintaining proper protein folding and quality control mechanisms within the cell.
Dysregulation of PDIA6 has been implicated in a variety of diseases, including neurodegenerative disorders and cancer. By studying the function of PDIA6, researchers can gain insight into the underlying mechanisms of these diseases and develop potential therapeutic strategies.Overall, the PDIA6 Polyclonal Antibody (CAB7055) is a valuable tool for researchers interested in understanding the role of PDIA6 in cellular function and disease pathology. Its specificity and reliability make it an ideal choice for studies in cell biology, biochemistry, and drug discovery.
Product Name:
PDIA6 Rabbit Polyclonal Antibody
SKU:
CAB7055
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 20-300 of human PDIA6 (NP_005733.1).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, a TRX-like domain, and a C-terminal ER-retention sequence. This protein inhibits the aggregation of misfolded proteins and exhibits both isomerase and chaperone activity. Alternative splicing results in multiple transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
10130
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDIA6 Rabbit pAb (CAB7055) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
