The PDIA3 Polyclonal Antibody (CAB1085) is a valuable tool for researchers studying PDIA3, a key protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, is highly specific to human PDIA3 and has been validated for use in Western blot applications. By binding to PDIA3, the antibody allows for detection and analysis of this important protein in a variety of cell types.PDIA3, also known as protein disulfide-isomerase A3, plays a crucial role in ensuring proper protein folding and assembly, as well as in regulating cellular redox balance.
Dysregulation of PDIA3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. By studying PDIA3 using this antibody, researchers can gain insights into the role of protein folding in various physiological and pathological processes.Overall, the PDIA3 Polyclonal Antibody (CAB1085) is a valuable tool for investigating the function of PDIA3 in health and disease, making it a useful asset for researchers in the fields of cell biology, biochemistry, and molecular biology.
Product Name:
ERp57 Rabbit Polyclonal Antibody
SKU:
CAB1085
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 206-505 of human ERp57 (NP_005304.3).
This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates.
Purification Method:
Affinity purification
Gene ID:
2923
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using ERp57 Rabbit pAb (CAB1085) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
