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PDIA3 Monoclonal Antibody [PAT9E9AT] (CPAB0232)

SKU:
CPAB0232
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Host Species:
Mouse
Isotype:
IgG2a
Clone:
PAT9E9AT
Applications:
ELISA
FC
€149
Frequently bought together:

Description

system_update_alt Datasheet

PDIA3 Monoclonal Antibody [PAT9E9AT] (CPAB0232)

The PDIA3 Polyclonal Antibody (CPAB0232) is a valuable tool for researchers studying PDIA3, a protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By binding to PDIA3, the antibody allows for the detection and analysis of this important protein in various cell types, making it ideal for studies in areas such as cell biology, protein folding, and ER stress response.PDIA3, also known as protein disulfide-isomerase A3, plays a crucial role in maintaining cellular protein homeostasis by facilitating the correct folding of newly synthesized proteins and assisting in the repair of misfolded proteins.

Dysregulation of PDIA3 has been implicated in various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases. By studying PDIA3, researchers can gain insights into the mechanisms underlying these conditions and potentially identify novel therapeutic targets for intervention.

Product Name:PDIA3 Antibody
Product Sku:CPAB0232
Size:5μg
Host Species:Mouse
Immunogen:Anti-human PDIA3 mAb, is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human PDIA3 protein 25-55 amino acids purified from Ecoli.
Clone:PAT9E9AT.
Reactivity:Human
Applications:ELISA, Flow Cytometry
Purification Method:PDIA3 antibody was purified from mouse ascitic fluids by protein-A affinity chromatography.
Isotype:IgG2a
Background:PDIA3 is an enzyme that belongs to the endoplasmic reticulum and interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. PDIA3 has protein disulfide isomerase activity. Complexes of lectins and PDIA3 mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. PDIA3 is expressed in the lumbar spinal cord from rats submitted to peripheral lesion during neonatal period. PDIA3 interacts with thiazide-sensitive sodium-chloride cotransporter in the kidney and is induced by glucose deprivation. PDIA3 is part of the major histocompatibility complex (MHC) class I peptide-loading complex (TAP1), which is important for formation of the final antigen conformation and export from the endoplasmic reticulum to the cell surface.
Synonyms:ERp57, ERp60, ERp61, GRP57, GRP58, HsT17083, P58, PI-PLC, ER60, Protein disulfide-isomerase A3, Disulfide isomerase ER-60, Endoplasmic reticulum resident protein 60, ER protein 60, 58 kDa microsomal protein, Endoplasmic reticulum resident protein 57, ER protein 57, 58 kDa glucose-regulated protein, PDIA3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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