The PDIA2 Polyclonal Antibody (CAB12789) is a valuable tool for researchers studying PDIA2, a protein involved in protein folding and quality control in the endoplasmic reticulum. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PDIA2 protein, this antibody allows for accurate detection and analysis in various cell types, making it an essential component for studies in molecular biology and protein research.PDIA2, also known as protein disulfide isomerase A2, plays a crucial role in maintaining protein integrity and function by facilitating the formation and rearrangement of disulfide bonds.
Dysregulation of PDIA2 has been linked to numerous diseases, including cancer, neurodegenerative disorders, and diabetes. Investigating the functions of PDIA2 is essential for gaining insights into these pathologies and developing targeted therapeutic interventions.With its high specificity and sensitivity, the PDIA2 Polyclonal Antibody (CAB12789) offers researchers a reliable tool for exploring the role of PDIA2 in health and disease, ultimately furthering our understanding of protein folding mechanisms and potential therapeutic targets.
Product Name:
PDIA2 Rabbit Polyclonal Antibody
SKU:
CAB12789
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 326-525 of human PDIA2 (NP_006840.2).
This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, two catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. The protein plays a role in the folding of nascent proteins in the endoplasmic reticulum by forming disulfide bonds through its thiol isomerase, oxidase, and reductase activity. The encoded protein also possesses estradiol-binding activity and can modulate intracellular estradiol levels.
Purification Method:
Affinity purification
Gene ID:
64714
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDIA2 Rabbit pAb (CAB12789) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
