Pdia2 Antibody (PACO28874)
- SKU:
- PACO28874
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Pdia2 Antibody (PACO28874)
The PDIA2 Polyclonal Antibody (PACO28874) is a valuable tool for research involving PDIA2, a protein associated with protein folding and cellular stress response. This antibody, produced in rabbits, is highly specific to PDIA2 in human samples and is optimized for use in Western blotting applications. PDIA2, also known as protein disulfide isomerase A2, plays a critical role in ensuring proper protein folding and quality control in the endoplasmic reticulum. Dysregulation of PDIA2 has been linked to various diseases, including cancer, neurodegenerative disorders, and cardiovascular diseases.
By using the PDIA2 Polyclonal Antibody, researchers can effectively detect and study PDIA2 levels in different cell types, providing valuable insights into its function and potential as a therapeutic target. This antibody is a valuable tool for studies in cell biology, protein folding, and disease mechanisms related to PDIA2 dysregulation.
| Antibody Name: | Pdia2 Antibody (PACO28874) |
| Antibody SKU: | PACO28874 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Protein disulfide-isomerase A2 protein (21-527AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot All lanes: Pdia2 antibody at 10µg/ml + Hela whole cell lysate Secondary Goat polyclonal to rabbit IgG at 1/10000 dilution Predicted band size: 59, 58 kDa Observed band size: 59 kDa . |
| Background: | Acts as an intracellular estrogen-binding protein. May be involved in modulating cellular levels and biological functions of estrogens in the pancreas. May act as a chaperone that inhibits aggregation of misfolded proteins. |
| Synonyms: | Protein disulfide-isomerase A2 (EC 5.3.4.1) (PDIp), Pdia2, Pdip |
| UniProt Protein Function: | |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008] |
| UniProt Code: | D3Z6P0 |
| NCBI GenInfo Identifier: | 20070125 |
| NCBI Gene ID: | 5034 |
| NCBI Accession: | NP_000909.2 |
| UniProt Secondary Accession: | D3Z6P0,Q13087, D3Z6P0 |
| UniProt Related Accession: | D3Z6P0,P07237 |
| Molecular Weight: | 58kDa |
| NCBI Full Name: | protein disulfide-isomerase |
| NCBI Synonym Full Names: | prolyl 4-hydroxylase subunit beta |
| NCBI Official Symbol: | P4HBÂ Â |
| NCBI Official Synonym Symbols: | DSI; GIT; PDI; PHDB; PDIA1; PO4DB; PO4HB; PROHB; CLCRP1; ERBA2L; P4Hbeta  |
| NCBI Protein Information: | protein disulfide-isomerase |
| UniProt Protein Name: | Protein disulfide-isomerase |
| UniProt Synonym Protein Names: | Cellular thyroid hormone-binding protein; Prolyl 4-hydroxylase subunit beta; p55 |
| Protein Family: | |
| UniProt Gene Name: | P4HBÂ Â |
| UniProt Entry Name: | PDIA1_HUMAN |
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