PDGFRB Rabbit Polyclonal Antibody (CAB2180)
- SKU:
- CAB2180
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
Product Name: | PDGFRB Rabbit Polyclonal Antibody |
SKU: | CAB2180 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PDGFRB (NP_002600.1). |
Sequence: | DSDA YYVY RLQV SSIN VSVN AVQT VVRQ GENI TLMC IVIG NEVV NFEW TYPR KESG RLVE PVTD FLLD MPYH IRSI LHIP SAEL EDSG TYTC NVTE SVND H |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:500 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | IMF1; KOGS; IBGC4; JTK12; PDGFR; PENTT; CD140B; PDGFR1; PDGFR-1; PDGFRB |
Positive Sample: | SH-SY5Y,mouse lung,NIH/3T3,C2C12 |
Conjugate: | Unconjugated |
Cellular Localization: | Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein. |
Calculated MW: | 124kDa |
Observed MW: | 200kDa |
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.
Purification Method: | Affinity purification |
Gene ID: | 5159 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |