The PDGFRB Polyclonal Antibody (CAB2180) is a vital tool for researchers studying the PDGFRB protein, a key player in cell growth and development. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the PDGFRB protein, this antibody enables accurate detection and analysis in a variety of cell types, making it a valuable asset for studies in molecular biology and cancer research.PDGFRB, also known as platelet-derived growth factor receptor beta, is essential for cell proliferation, migration, and survival, making it a target of interest in cancer research and other diseases involving abnormal cell growth.
Understanding the role of PDGFRB in signaling pathways and cellular processes is crucial for developing targeted therapies for conditions such as cancer, fibrosis, and vascular disorders. The PDGFRB Polyclonal Antibody (CAB2180) provides researchers with a reliable tool to further explore the functions and therapeutic potential of this important protein.
Product Name:
PDGFRB Rabbit Polyclonal Antibody
SKU:
CAB2180
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 200-300 of human PDGFRB (NP_002600.1).
Cell membrane, Cytoplasmic vesicle, Lysosome lumen, Single-pass type I membrane protein.
Calculated MW:
124kDa
Observed MW:
200kDa
The protein encoded by this gene is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer (PDGFB or PDGFD) or a heterodimer (PDGFA and PDGFB). This gene is essential for normal development of the cardiovascular system and aids in rearrangement of the actin cytoskeleton. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulating factor and macrophage-colony stimulating factor receptor; all three genes may be implicated in the 5-q syndrome. A translocation between chromosomes 5 and 12, that fuses this gene to that of the ETV6 gene, results in chronic myeloproliferative disorder with eosinophilia.
Purification Method:
Affinity purification
Gene ID:
5159
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDGFRB Rabbit pAb (CAB2180) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 3min.
