The PDGFRA Polyclonal Antibody (CAB2103) is a valuable tool for researchers studying PDGFRA, a cell surface receptor involved in cell growth and division. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the PDGFRA protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in cell biology, cancer research, and developmental biology.PDGFRA, also known as platelet-derived growth factor receptor alpha, is a crucial player in cell proliferation and differentiation processes, making it a key target for research into cancer biology, developmental disorders, and tissue regeneration.
Understanding the role of PDGFRA in cell signaling pathways is essential for developing novel therapeutic strategies that target this receptor to treat diseases such as cancer and fibrosis.Overall, the PDGFRA Polyclonal Antibody (CAB2103) offers researchers a reliable tool for studying the functions of PDGFRA in various biological processes and diseases, ultimately advancing our understanding of cell signaling mechanisms and offering new insights for targeted therapies.
Product Name:
PDGFRA Rabbit Polyclonal Antibody
SKU:
CAB2103
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 896-1059 of human PDGFR alpha (NP_006197.1).
Cell membrane, Single-pass type I membrane protein.
Calculated MW:
123kDa
Observed MW:
150-190kDa
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies suggest that this gene plays a role in organ development, wound healing, and tumor progression. Mutations in this gene have been associated with idiopathic hypereosinophilic syndrome, somatic and familial gastrointestinal stromal tumors, and a variety of other cancers.
Purification Method:
Affinity purification
Gene ID:
5156
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using PDGFR alpha Rabbit pAb (CAB2103) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
