Pdgfd Antibody (PACO46970)
- SKU:
- PACO46970
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IF
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
Pdgfd Antibody (PACO46970)
The PDGFD Polyclonal Antibody (PAC046970) offered by Assay Genie is a valuable tool for researchers studying PDGFD, a growth factor protein involved in various cellular processes, including cell proliferation, migration, and differentiation. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for Western blot applications.PDGFD is known for its role in promoting angiogenesis and tissue repair, making it a promising target for studies related to cardiovascular diseases, cancer, and wound healing. By specifically binding to the PDGFD protein, this antibody enables researchers to detect and analyze its expression in different cell types, providing valuable insights into its function and potential therapeutic applications.
Furthermore, understanding the mechanisms of PDGFD signaling and its impact on cellular pathways is essential for developing targeted therapies for diseases where PDGFD dysregulation is implicated. With its reliability and specificity, the PDGFD Polyclonal Antibody from Assay Genie is a valuable tool for advancing research in the fields of molecular biology and biomedicine.
| Antibody Name: | Pdgfd Antibody (PACO46970) |
| Antibody SKU: | PACO46970 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IF |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IF:1:50-1:200 |
| Species Reactivity: | Mouse, Human |
| Immunogen: | Recombinant Mouse Platelet-derived growth factor D protein (24-370AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescent analysis of HepG2 cells using PACO46970 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Western Blot. Positive WB detected in: A549 whole cell lysate, Hela whole cell lysate. All lanes: Pdgfd antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 43, 31 kDa. Observed band size: 43 kDa. |
| Background: | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing (By similarity). Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. |
| Synonyms: | Platelet-derived growth factor D (PDGF-D) (Spinal cord-derived growth factor B) (SCDGF-B) [Cleaved into: Platelet-derived growth factor D, latent form (PDGFD latent form); Platelet-derived growth factor D, receptor-binding form (PDGFD receptor-binding form)], Pdgfd, Scdgfb |
| UniProt Protein Function: | PDGFD: Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix. Belongs to the PDGF/VEGF growth factor family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Secreted; Oncoprotein; Secreted, signal peptide Cellular Component: extracellular region; extracellular space; membrane Molecular Function:growth factor activity; platelet-derived growth factor receptor binding Biological Process: cellular process; multicellular organismal development; platelet-derived growth factor receptor signaling pathway; positive regulation of cell division; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of protein amino acid autophosphorylation; positive regulation of smooth muscle cell proliferation; regulation of peptidyl-tyrosine phosphorylation |
| UniProt Code: | Q925I7 |
| NCBI GenInfo Identifier: | 27229137 |
| NCBI Gene ID: | 71785 |
| NCBI Accession: | NP_082200.1 |
| UniProt Secondary Accession: | Q925I7,Q3URF6, Q8K2L3, Q9D1L8, |
| UniProt Related Accession: | Q925I7 |
| Molecular Weight: | 56.2 kDa |
| NCBI Full Name: | platelet-derived growth factor D |
| NCBI Synonym Full Names: | platelet-derived growth factor, D polypeptide |
| NCBI Official Symbol: | Pdgfd  |
| NCBI Official Synonym Symbols: | 1110003I09Rik  |
| NCBI Protein Information: | platelet-derived growth factor D |
| UniProt Protein Name: | Platelet-derived growth factor D |
| UniProt Synonym Protein Names: | Spinal cord-derived growth factor B; SCDGF-B |
| Protein Family: | Platelet-derived growth factor |
| UniProt Gene Name: | Pdgfd  |
| UniProt Entry Name: | PDGFD_MOUSE |
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