The PDGF Polyclonal Antibody (CAB17434) is a powerful tool for researchers studying PDGF, a growth factor involved in cell proliferation, migration, and survival. This antibody, produced in rabbits, exhibits high reactivity specifically with human samples, making it ideal for use in Western blot applications. By binding to the PDGF protein, this antibody enables precise detection and analysis in a variety of cell types, making it essential for investigations in the fields of cell biology, cancer research, and tissue regeneration.
PDGF, or platelet-derived growth factor, plays a crucial role in various physiological processes, including wound healing, angiogenesis, and tissue repair. Dysregulation of PDGF signaling has been linked to diseases such as cancer, fibrotic disorders, and cardiovascular conditions. Therefore, understanding the mechanisms of PDGF action is fundamental for developing targeted therapies and interventions aimed at controlling cell growth and tissue regeneration in pathological settings.
Product Name:
PDGFA Rabbit Polyclonal Antibody
SKU:
CAB17434
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 21-110 of human PDGFA (NP_002598.4).
Sequence:
EEAE IPRE VIER LARS QIHS IRDL QRLL EIDS VGSE DSLD TSLR AHGV HATK HVPE KRPL PIRR KRSI EEAV PAVC KTRT VIYE IPRS QV
This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or alternatively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental processes. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
5154
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded human esophageal using PDGFA Rabbit pAb (CAB17434) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM Tris/EDTA buffer pH 9.0 before commencing with IHC staining protocol.
